Quy Ho Quang, Thanh Thai Doan, Tuan Doan Quoc, Le Ly Nguyen & Thang Nguyen Manh
The positioning of the trapped bead and DNA’s stretching dynamics in the nonlinear optical tweezers are numerically simulated by finite difference method using general Langevin. From the performance of longitudinal position-pulling time curves of bead and evolution of forces controlled by average laser power, the trapping time, possible maximum stretched length, and laser intensity threshold of to broken DNA molecule are found. We also discussed the suitable conditions to avoid broken and overstretched states for longitudinally optical stretched DNA molecule. Finally, the optimized configuration of NOT for DNA molecules having different contour lengths is proposed.
DOI
Showing posts with label Optical and Quantum Electronics. Show all posts
Showing posts with label Optical and Quantum Electronics. Show all posts
Monday, September 21, 2020
Wednesday, January 22, 2020
3D control stretched length of lambda-phage WLC DNA molecule by nonlinear optical tweezers
Thang Nguyen Manh, Quy Ho Quang, Thanh Thai Doan, Tuan Doan Quoc, Viet Do Thanh & Khoa Doan Quoc
In this paper, the general Langevin equations of motion for the polystyrene bead linked to the lambda-phage worm-like chain DNA molecule embedded in the fluid under the nonlinear optical tweezers is derived in 3D space. Using the finite difference method, the dynamical properties of the bead trapped by the nonlinear optical tweezers using a thin layer of Acid Blue 29 are numerically studied. Results in, the stretched length of the lambda-phage worm-like chain DNA molecule can be controlled in 3D space by finely tuning of the laser power.
DOI
In this paper, the general Langevin equations of motion for the polystyrene bead linked to the lambda-phage worm-like chain DNA molecule embedded in the fluid under the nonlinear optical tweezers is derived in 3D space. Using the finite difference method, the dynamical properties of the bead trapped by the nonlinear optical tweezers using a thin layer of Acid Blue 29 are numerically studied. Results in, the stretched length of the lambda-phage worm-like chain DNA molecule can be controlled in 3D space by finely tuning of the laser power.
DOI
Wednesday, June 13, 2018
Optical manipulation of microparticles with a fiber tip containing a hollow cavity
Xiaoqi Ni, Ming Wang, Ri Wang, Yan Huang, Yiping Wang, Dongmei Guo
Optical manipulation is a non-contact and non-destructive method to capture and manipulate micro/nano particles, biological macromolecules and cells with application of optical forces. With the rapid development of optical manipulation, various kinds of optical fiber tips have been presented and demonstrated in recent years. In this letter, a novel structure of optical fiber tip with an imbedded hollow cavity is presented. The electric field distribution of the fiber tip and the influence of cavity geometry are simulated with finite-difference time-domain method. The unique advantage is that the electric field intensity will be significantly enhanced when the fiber tip is filled with high refractive index medium in the cavity, which brings the potential to generate a three-dimensional optical trap for particles. Through experiments, we also demonstrate that the velocity of the particles driven by the optical force has a quadratic relationship with the laser power. The relationship can be used in microfluidic technology to measure the velocity of micro fluid. And the balance between the scattering force and the fluid force can be used to study non-invasive migration of particles.
DOI
Optical manipulation is a non-contact and non-destructive method to capture and manipulate micro/nano particles, biological macromolecules and cells with application of optical forces. With the rapid development of optical manipulation, various kinds of optical fiber tips have been presented and demonstrated in recent years. In this letter, a novel structure of optical fiber tip with an imbedded hollow cavity is presented. The electric field distribution of the fiber tip and the influence of cavity geometry are simulated with finite-difference time-domain method. The unique advantage is that the electric field intensity will be significantly enhanced when the fiber tip is filled with high refractive index medium in the cavity, which brings the potential to generate a three-dimensional optical trap for particles. Through experiments, we also demonstrate that the velocity of the particles driven by the optical force has a quadratic relationship with the laser power. The relationship can be used in microfluidic technology to measure the velocity of micro fluid. And the balance between the scattering force and the fluid force can be used to study non-invasive migration of particles.
DOI
Tuesday, April 24, 2018
Acousto-optical tweezers for stretch of DNA molecule
Thanh Thai Doan, Khoa Doan Quoc, Quy Ho Quang
The appearance of microlenses in the amorphous crystal Ge33As12Se33 modulated by the acoustic waves with intensity of 107 W/m2 and frequency of (200–400) MHz is presented. The flexibility of microlens, i.e. the dependence of its focal point in 3D space on the parameters of acoustic wave is studied. Basing on flexibility of microlens, a model of acousto-optical tweezers to stretch the λ-phage WLC DNA molecule is proposed. And then the control process of stretched length of DNA molecule in 3D space of the water (fluid) by calibration of the acoustic frequency is numerically observed and discussed. The obtained results show the possibility to use the acousto-optical tweezers to control the stretched length of WLC DNA molecule with high fineness.
DOI
The appearance of microlenses in the amorphous crystal Ge33As12Se33 modulated by the acoustic waves with intensity of 107 W/m2 and frequency of (200–400) MHz is presented. The flexibility of microlens, i.e. the dependence of its focal point in 3D space on the parameters of acoustic wave is studied. Basing on flexibility of microlens, a model of acousto-optical tweezers to stretch the λ-phage WLC DNA molecule is proposed. And then the control process of stretched length of DNA molecule in 3D space of the water (fluid) by calibration of the acoustic frequency is numerically observed and discussed. The obtained results show the possibility to use the acousto-optical tweezers to control the stretched length of WLC DNA molecule with high fineness.
DOI
Friday, December 9, 2016
3D controlling the bead linking to DNA molecule in a single-beam nonlinear optical tweezers
Trung Thai Dinh, Khoa Doan Quoc, Kien Bui Xuan, Quy Ho Quang
The approximate expressions describing the redistribution of laser beam and optical forces in Kerr fluid, and the ratio of refractive indexes basing on the optical Kerr effect in fluid are derived. Basing on them, the dynamic of nonlinear bead in the nonlinear fluid is simulated by the finite different Langevin equation in presence of the optical Kerr and self-focused effects. The radial and axial control processes of bead linking to λ-phage WLC DNA molecule in fluid space are numerically observed by calibration of the laser power under and upper the critical value, respectively. The stable position-laser power characteristics are numerically found out. Based on the results, a sample of single-beam optical tweezers for 3D (axial and radial) control of bead is proposed and discussed.
DOI
The approximate expressions describing the redistribution of laser beam and optical forces in Kerr fluid, and the ratio of refractive indexes basing on the optical Kerr effect in fluid are derived. Basing on them, the dynamic of nonlinear bead in the nonlinear fluid is simulated by the finite different Langevin equation in presence of the optical Kerr and self-focused effects. The radial and axial control processes of bead linking to λ-phage WLC DNA molecule in fluid space are numerically observed by calibration of the laser power under and upper the critical value, respectively. The stable position-laser power characteristics are numerically found out. Based on the results, a sample of single-beam optical tweezers for 3D (axial and radial) control of bead is proposed and discussed.
DOI
Wednesday, August 10, 2016
Theoretical and experimental studies on optical trapping using radially polarized beams
Zhehai Zhou, Yuling Zhang, Lianqing Zhu
Optical trapping using radially polarized beams is studied theoretically and experimentally. First the geometric ray model is introduced to calculate the trapping efficiencies, and simulation results using three kinds of pupil apodization functions are presented to disclose the influences of pupil apodization functions of incident beams on trapping efficiencies, which indicates the better trapping performances can be achieved by modulating the polarization and amplitude distributions of incident beams using designated pupil filters. Furthermore, the optical tweezers using radially polarized beams are built up based on an inverted microscope and a spatial light modulator (SLM), where better trapping efficiencies can be achieved. Yeast cells about 10μm in diameter are trapped and manipulated using the optical tweezers and the cells can be trapped stably and shifted along the tracks of the focusing spot, which can be programmed by a computer. In addition, the values of trap stiffness for different pupil apodization functions are measured at different laser powers based on the Boltzmann statistics method, which indicates the AL-types pupil apodization function is a better choice for general trapping and manipulation of cells.
DOI
Optical trapping using radially polarized beams is studied theoretically and experimentally. First the geometric ray model is introduced to calculate the trapping efficiencies, and simulation results using three kinds of pupil apodization functions are presented to disclose the influences of pupil apodization functions of incident beams on trapping efficiencies, which indicates the better trapping performances can be achieved by modulating the polarization and amplitude distributions of incident beams using designated pupil filters. Furthermore, the optical tweezers using radially polarized beams are built up based on an inverted microscope and a spatial light modulator (SLM), where better trapping efficiencies can be achieved. Yeast cells about 10μm in diameter are trapped and manipulated using the optical tweezers and the cells can be trapped stably and shifted along the tracks of the focusing spot, which can be programmed by a computer. In addition, the values of trap stiffness for different pupil apodization functions are measured at different laser powers based on the Boltzmann statistics method, which indicates the AL-types pupil apodization function is a better choice for general trapping and manipulation of cells.
DOI
Thursday, April 14, 2016
Investigating the use of a hybrid plasmonic–photonic nanoresonator for optical trapping using finite-difference time-domain method
M. Mossayebi , A. J. Wright, A. Parini, M. G. Somekh, G. Bellanca, E. C. Larkins
We investigate the use of a hybrid nanoresonator comprising a photonic crystal (PhC) cavity coupled to a plasmonic bowtie nanoantenna (BNA) for the optical trapping of nanoparticles in water. Using finite-difference time-domain simulations, we show that this structure can confine light to an extremely small volume of ∼30,000nm3(∼30∼30,000nm3(∼30 zl) in the BNA gap whilst maintaining a high quality factor (5400–7700). The optical intensity inside the BNA gap is enhanced by a factor larger than 40 compared to when the BNA is not present above the PhC cavity. Such a device has potential applications in optical manipulation, creating high precision optical traps with an intensity gradient over a distance much smaller than the diffraction limit, potentially allowing objects to be confined to much smaller volumes and making it ideal for optical trapping of Rayleigh particles (particles much smaller than the wavelength of light).
DOI
We investigate the use of a hybrid nanoresonator comprising a photonic crystal (PhC) cavity coupled to a plasmonic bowtie nanoantenna (BNA) for the optical trapping of nanoparticles in water. Using finite-difference time-domain simulations, we show that this structure can confine light to an extremely small volume of ∼30,000nm3(∼30∼30,000nm3(∼30 zl) in the BNA gap whilst maintaining a high quality factor (5400–7700). The optical intensity inside the BNA gap is enhanced by a factor larger than 40 compared to when the BNA is not present above the PhC cavity. Such a device has potential applications in optical manipulation, creating high precision optical traps with an intensity gradient over a distance much smaller than the diffraction limit, potentially allowing objects to be confined to much smaller volumes and making it ideal for optical trapping of Rayleigh particles (particles much smaller than the wavelength of light).
DOI
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