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Wednesday, February 22, 2012

Intramolecular folding in three tandem guanine repeats of human telomeric DNA

Deepak Koirala , Tomoko Mashimo , Yuta Sannohe , Zhongbo Yu , Hanbin Mao and Hiroshi Sugiyama

Intramolecular folding in three tandem guanine repeats of human telomeric DNA has been investigated using optical-tweezers, MD simulation and circular dichroism. A mechanically and thermodynamically stable species in this sequence shows a structure consistent with a triplex conformation. A similar species has also been observed to coexist with a G-quadruplex in a DNA sequence with four tandem guanine repeats.

DOI

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