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Thursday, January 19, 2012

Three powerful research tools from single cells into single molecules: AFM, laser tweezers, and raman spectroscopy

Wu, Y., Liu, K., Song, K., Pan, S.

By using three physical techniques (atomic force microscopy (AFM), laser tweezers, and Raman spectroscopy), many excellent works in single-cell/molecule research have been accomplished. In this review, we present a brief introduction to the principles of these three techniques, and their capabilities toward single-cell/ molecule research are highlighted. Afterward, the advances in single-cell/molecule research that have been facilitated by these three techniques are described. Following this, their complementary assets for single-cell/molecule research are analyzed, and the necessity of integrating the functions of these three techniques into one instrument is proposed.

DOI

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