Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.
Friday, December 4, 2009
Determining the Zero-Force Binding Energetics of an Intercalated DNA Complex by a Single-Molecule Approach
Tzu-Sen Yang, Yujia Cui, Chien-Ming Wu, Jem-Mau Lo, Chi-Shiun Chiang, Wun-Yi Shu, Wei-Ju Chung, Chung-Shan Yu, Kuo-Ning Chiang, Ian C. Hsu
Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.
Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.
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