Optical trapping assisted detection rate enhancement of single molecules on a nanopore optofluidic chip

M. Rahman, M. Harrington, M. A. Stott, Y. Li, M. J. N. Sampad, T. D. Yuzvinsky, A. R. Hawkins, and H. Schmidt

We use optical trapping to deliver molecular targets to the vicinity of a nanopore for high-throughput single molecule analysis on an optofluidic chip. DNA detection rates increase over 80× to enable detection at attomolar concentrations.

DOI