Jie Yang, Ruo-Nan Zhang, Dong-Jie Liu, Xu Zhou, Tatsuya Shoji, Yasuyuki Tsuboi and Hu Yan
We have immobilized poly(ethylene glycol) (PEG) on surface of poly(lactic-co-glycolic acid) (PLGA) nanoparticles by two different chemical methods, i.e., SOCl2 halogennate-alcoholysis and DCC dehydration. The immobilized PLGA nanoparticles were characterized by DLS, 1H NMR, FT-IR and laser trapping/confocal Raman spectroscopic technique. As a result, especially the Raman spectra which were measured after optically trapping less than ten individual nanoparticles in solution, indicated that the PLGA nanoparticles were successfully immobilized with the PEG by the chemical method.
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