The micro/nanofluidic technique has become an important tool for single-cell analysis with the capability to integrate time-consuming and labour-intensive experimental procedures into a small device. Micro/nanofluidics-based biochemical analysis exhibits advantages over conventional methods in terms of small sample volume, rapid turnaround time, straightforward operation, and efficient processing. Single-cell manipulation, therapy, detection and sequencing could be implemented within a sophisticated and multi-functional micro/nanofluidic platform. Here we review recent developments of micro/nanofluidic technologies for single-cell analysis, with emphasis on cell trapping, treatment, and biochemical studies. The potential of micro/nanofluidics-based single-cell analysis is discussed.
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