Parthiv Chaudhuri, Majid Ebrahimi Warkiani, Tengyang Jing, Kenry Kenry and Chwee Teck Lim
Cancer is currently one of the top non-communicable human diseases and continual research and developmental efforts are being made to better understand and manage this disease. More recently, with improved understanding in cancer biology as well as advancement made in microtechnology and rapid prototyping, microfluidics is increasingly being explored and even validated for use in the detection, diagnosis and treatment of cancer. With inherent advantages such as small sample volume, high sensitivity and fast processing time, microfluidics is well-positioned to serve as a promising platform for applications in oncology. In this review, we look at recent advances in the use of microfluidics - from basic research such as understanding cancer cell phenotypes as well as metastatic behaviors to applications such as detection, diagnosis, prognosis and drug screening. We then conclude with a future outlook on this promising technology.
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