Tuesday, May 5, 2015

Diagnostic Tools for Lab-on-Chip Applications Based on Coherent Imaging Microscopy

Merola, F.; Memmolo, P. ; Miccio, L. ; Bianco, V. ; Paturzo, M. ; Ferraro, P.

Today, fast and accurate diagnosis through portable and cheap devices is in high demand for the general healthcare. Lab-on-chips (LoCs) have undergone a great growth in this direction, supported by optical imaging techniques more and more refined. Here we present recent progresses in developing imaging tools based on coherent imaging microscopy that can be very useful when applied into biomicrofluidics. In some cases, the optical tweezers (OT) technique is combined with digital holography (DH), thus offering the possibility to manipulate, analyze, and measure fundamental parameters of different kinds of cells. This approach can open the route for rapid and high-throughput analysis in label-free microfluidic devices and for prognostic based on cell examination, thus allowing advancements in biomedical science.

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