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Thursday, April 16, 2015

Biodegradable PLGA Nanoparticles Loaded with Hydrophobic Drugs: Confocal Raman Microspectroscopic Characterization

Hu Yan, Yi-Fan Hou, Peng-Fei Niu, Ke Zhang, Tatsuya Shoji, Yasuyuki Tsuboi, Fang-Yao Yao, Li-Min Zhao and Junbiao Chang

Poly(lactic-co-glycolic acid) (PLGA) nanoparticles with bicyclol (5%) and 3-n-butyl-6-bromophthalid (Br-NBP) (3%) were prepared by an emulsification-solvent evaporation technique. The PLGA nanoparticles were for the first time successfully characterized by a laser trapping/confocal Raman spectroscopic technique only using individual PLGA nanoparticles. This technique allowed us to selectively obtain Raman spectra of optically trapped PLGA nanoparticles (~ 10 nanoparticles) in solution. The Raman spectrum of PLGA nanoparticles loaded with hydrophobic drugs showed that these drugs were certainly incorporated in the nanoparticles.

DOI
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