Yuquan Zhang, Xiaojing Wu, Changjun Min, Siwei Zhu, Xiaodong Yuan, and Paul Urbach
Monitoring the cells’ apoptosis progression could provide a valuable insight into the
temporal events that initiate cell death as well as the potential for rescue of apoptotic cells. In
this paper, we engineered a novel and robust method for monitoring apoptosis of tumor
cellsbased on dynamic laser tweezers, using A549 and HeLa cell line as typical samples. The entire experiment can be completed in a few hours withsmall amount of fluid sample, presenting great advantages of celerity, micro-scaled measurement, and label-free explorations without perturbing experimental conditions in combination with other probes. Validity and stability of this method are verified experimentally in terms of physical parameters of the system. The proposed technique hasgreat potential in improving cancer treatment by monitoring the objective efficacy of tumor cell killing.
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