Monday, February 3, 2014

Single Cell Transfection with Single Molecule Resolution Using a Synthetic Nanopore

Volker Kurz , Tetsuya Tanaka , and Gregory Timp

We report the development of a single cell gene delivery system based on electroporation using a synthetic nanopore, that is not only highly specific and very efficient, but also transfects with single molecule resolution at low voltage (1V) with minimal perturbation to the cell. Such a system can be used to control gene expression with unprecedented precision—no other method offers such capabilities.

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