Wednesday, May 8, 2013

Dynamic optical tweezers based assay for monitoring early drug resistance

Xiaojing Wu, Yuquan Zhang, Changjun Min, Siwei Zhu, Jie Feng and X-C Yuan
In this letter, a dynamic optical tweezers based assay is proposed and investigated for monitoring early drug resistance with Pemetrexed-resistant non-small cell lung cancer (NSCLC) cell lines. The validity and stability of the method are verified experimentally in terms of the physical parameters of the optical tweezers system. The results demonstrate that the proposed technique is more convenient and faster than traditional techniques when the capability of detecting small variations of the response of cells to a drug is maintained.
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