The aim of this work is to investigate if the optical tweezers (OT) are suitable as a diagnostic tool for monitoring the oligodeoxyribonucleotide (ODN) structural behavior in solution. Preliminary experiments, performed on the quadruplex formed by the ODN sequence TGGGGT, showed that the OT can be used as a probe for ODN structuration by monitoring the medium viscosity changes associated with ODN folding-unfolding processes.
Monday, May 10, 2010
Optical Tweezers as a Probe for Oligodeoxyribonucleotide Structuration
Nicola Borbone; Giorgia Oliviero; Jussara Amato; Gennaro Piccialli; Luciano Mayol; Lisa Miccio; Giuseppe Pesce; Antonio Sasso
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